I don't think the issues being experienced are directly related to the frameworks. Certainly not related to using an MVC based framework. These sites are struggling with scalability. It gets tricky once you have enough traffic to require dozens of servers.
Every new feature has ripple effects. Both these sites are growing big, fast, with only limited staff. It must be a blast to be working at either.
You can check out another great Django app over at
http://www.kountr.com. No scalability issues yet.
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